Temporal ordering of omics and multiomic events inferred from time-series data

Author:

Kaur Sandeep,Peters Timothy J.ORCID,Yang PengyiORCID,Luu Laurence Don WaiORCID,Vuong Jenny,Krycer James R.,O’Donoghue Seán I.ORCID

Abstract

AbstractTemporal changes in omics events can now be routinely measured; however, current analysis methods are often inadequate, especially for multiomics experiments. We report a novel analysis method that can infer event ordering at better temporal resolution than the experiment, and integrates omic events into two concise visualizations (event maps and sparklines). Testing our method gave results well-correlated with prior knowledge and indicated it streamlines analysis of time-series data.

Funder

Australian Diabetes Society Skip-Martin Early Career Fellowship.

Publisher

Springer Science and Business Media LLC

Subject

Applied Mathematics,Computer Science Applications,Drug Discovery,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation

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