Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

Author:

Mishra H1,Polak S12,Jamei M1,Rostami-Hodjegan A13

Affiliation:

1. Simcyp Limited (a Certara Company), Blades Enterprise Centre; Sheffield UK

2. Unit of Pharmacoepidemiology and Pharmacoeconomics, Faculty of Pharmacy; Jagiellonian University Medical College; Krakow Poland

3. Manchester Pharmacy School, University of Manchester; Manchester UK

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

Reference51 articles.

1. Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative;Piccini;Am. Heart J.,2009

2. International Conference on Harmonisation. The clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrythmic drugs http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E14/E14_Guideline.pdf

3. Pharmacokinetic-pharmacodynamic modeling in the data analysis and interpretation of drug-induced QT/QTc prolongation;Piotrovsky;AAPS J.,2005

4. Multiscale modelling of drug-induced effects on cardiac electrophysiological activity;Brennan;Eur. J. Pharm. Sci.,2009

5. Blockade of the I(Ks) potassium channel: an overlooked cardiovascular liability in drug safety screening?;Towart;J. Pharmacol. Toxicol. Methods,2009

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