Prediction of Metabolic Interactions With Oxycodone via CYP2D6 and CYP3A Inhibition Using a Physiologically Based Pharmacokinetic Model-Reference-Cited by-同舟云学术

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Prediction of Metabolic Interactions With Oxycodone via CYP2D6 and CYP3A Inhibition Using a Physiologically Based Pharmacokinetic Model

Published:2014-12 Issue:12 Volume:3 Page:152
ISSN:2163-8306
Container-title:CPT: Pharmacometrics & Systems Pharmacology
language:en
Short-container-title:CPT: Pharmacometrics & Systems Pharmacology

Author:

Marsousi N¹²,Daali Y¹³,Rudaz S²³,Almond L⁴,Humphries H⁴,Desmeules J¹³,Samer C F¹³

Affiliation:

1. Department of Clinical Pharmacology and Toxicology, Geneva University Hospitals, Geneva University; Geneva Switzerland

2. Department of Pharmaceutical Analytical Chemistry, School of Pharmaceutical Sciences, Geneva University; Geneva Switzerland

3. Swiss Centre for Applied Human Toxicology; Geneva Switzerland

4. Simcyp Limited (a Certara Company), Blades Enterprise Centre; Sheffield UK

Publisher

Wiley

Subject

Pharmacology (medical),Modelling and Simulation

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1038/psp.2014.49/fullpdf

Reference47 articles.

1. Oxycodone: a review of its use in the management of pain;Riley;Curr. Med. Res. Opin.,2008

2. The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects;Pöyhiä;Br. J. Clin. Pharmacol.,1992

3. Mu receptor binding of some commonly used opioids and their metabolites;Chen;Life Sci.,1991

4. Tentative identification of novel oxycodone metabolites in human urine;Moore;J. Anal. Toxicol.,2003

5. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes;Lalovic;Drug Metab. Dispos.,2004

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