Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations-Reference-Cited by-同舟云学术

Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations

Published:2015-06-29 Issue:8 Volume:7 Page:653-660
ISSN:1755-4330
Container-title:Nature Chemistry
language:en
Short-container-title:Nature Chem

Author:

Narayan Alison R. H.,Jiménez-Osés Gonzalo^ORCID,Liu Peng^ORCID,Negretti Solymar,Zhao Wanxiang,Gilbert Michael M.,Ramabhadran Raghunath O.,Yang Yun-Fang,Furan Lawrence R.,Li Zhe,Podust Larissa M.,Montgomery John,Houk K. N.,Sherman David H.

Publisher

Springer Science and Business Media LLC

Subject

General Chemical Engineering,General Chemistry

Link

http://www.nature.com/articles/nchem.2285.pdf

Reference61 articles.

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2. Gormisky, P. E. & White, M. C. Catalyst-controlled aliphatic C–H oxidations with a predictive model for site-selectivity. J. Am. Chem. Soc. 135, 14052–14055 (2013).

3. Chen, M. S. & White, M. C. Combined effects on selectivity in Fe-catalyzed methylene oxidation. Science 327, 566–571 (2010).

4. Chen, K., Eschenmoser, A. & Baran, P. S. Strain release in C–H bond activation. Angew. Chem. Int. Ed. 48, 9705–9708 (2009).

5. Roiban, G. D., Agudo, R. & Reetz, M. T. Cytochrome P450 catalyzed oxidative hydroxylation of achiral organic compounds with simultaneous creation of two chirality centers in a single C–H activation step. Angew. Chem. Int. Ed. 53, 8659–8663 (2014).

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