Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs

Author:

Li Jiang,Xu Shao-feng,Peng Ying,Feng Nan,Wang Ling,Wang Xiao-liang

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference41 articles.

1. Zhang Y, Wang L, Li J, Wang XL . 2-(1-Hydroxypentyl)-benzoate increases cerebral blood flow and reduces infarct volume in rats model of transient focal cerebral ischemia. J Pharmacol Exp Ther 2006; 317: 973–9.

2. XU Z, HU GY, TAN GS . Comparative research on methods of n-butylphthalide synthesis. China J Modern Med 2004; 14: 91–3.

3. Wang XW . 3-n-Butylphthalide. Drugs Future 2000; 25: 16–23.

4. Dong GX, Feng YP . Effects of NBP on ATPase and anti-oxidant enzymes activities and lipid peroxidation in transient focal cerebral ischemic rats. Acta Acad Med Sin 2002; 24: 93–7.

5. Cui LY, Liu XQ, Zhu YC, Fan DS, Xie RP, Shen Y, et al. Effects of dl-3-butylphthalide on treatment of acute ischemic stroke with moderate symptoms: a multi-center, randomized, double-bind, placebo-control trial. Chin J Neurol 2005; 38: 251–4.

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