Age-associated changes in gene regulatory relationships affect basic cellular processes
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s43587-024-00706-z.pdf
Reference5 articles.
1. Bahar, R. et al. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441, 1011–1014 (2006). This paper is one of the first reports of an age-associated increase in expression heterogeneity between single cells.
2. Warren, L. A. et al. Transcriptional instability is not a universal attribute of aging. Aging Cell 6, 775–782 (2007). This paper analyzed gene expression variation, focusing on immune cells, and did not find evidence for an increase in expression heterogeneity.
3. Avila, P. U. et al. Gene regulatory networks in disease and ageing. Nat. Rev. Nephrol. 20, 616–633 (2024). This review describes different types of gene regulatory networks and explains why gene expression can be predicted (within limits) using one generic network.
4. Lonsdale, J. et al. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45, 580–585 (2013). The GTEx data are a great resource for studying gene expression changes in human cohorts across diverse tissues.
5. Tarkhov, A. E. et al. Nature of epigenetic aging from a single cell perspective. Nat. Aging 4, 854–870 (2024). This paper reports that the molecular state of aged cells can be explained by a combination of stochastic effects that accumulate during aging and regulatory adaptation.
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