Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma-Reference-Cited by-同舟云学术

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Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

Published:2013-10-09 Issue:7474 Volume:503 Page:126-130
ISSN:0028-0836
Container-title:Nature
language:en
Short-container-title:Nature

Author:

Gerber Elizabeth E.,Gallo Elena M.,Fontana Stefani C.,Davis Elaine C.,Wigley Fredrick M.,Huso David L.,Dietz Harry C.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/nature12614.pdf

Reference39 articles.

1. Mayes, M. D. et al. Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population. Arthritis Rheum. 48, 2246–2255 (2003)

2. Harris, M. L. & Rosen, A. Autoimmunity in scleroderma: the origin, pathogenetic role, and clinical significance of autoantibodies. Curr. Opin. Rheumatol. 15, 778–784 (2003)

3. Loeys, B. L. et al. Mutations in fibrillin-1 cause congenital scleroderma: stiff skin syndrome. Sci. Transl. Med. 2, 23ra20 (2010)

4. Varga, J. & Pasche, B. Transforming growth factor β as a therapeutic target in systemic sclerosis. Nature Rev. Rheumatol. 5, 200–206 (2009)

5. Doyle, J. J., Gerber, E. E. & Dietz, H. C. Matrix-dependent perturbation of TGF-β signaling and disease. FEBS Lett. 586, 2003–2015 (2012)

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