Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Microbiology (medical),Genetics,Applied Microbiology and Biotechnology,Immunology,Microbiology
Link
http://www.nature.com/articles/nmicrobiol201534.pdf
Reference36 articles.
1. Cunha, B. A., Burillo, A. & Bouza, E. Legionnaires’ disease. Lancet http://dx.doi.org/10.1016/S0140-6736(15)60078-2 (2015).
2. Newton, H. J., Ang, D. K., van Driel, I. R. & Hartland, E. L. Molecular pathogenesis of infections caused by Legionella pneumophila. Clin. Microbiol. Rev. 23, 274–298 (2010).
3. O'Connor, T. J., Boyd, D., Dorer, M. S. & Isberg, R. R. Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science 338, 1440–1444 (2012).
4. Lock, K. et al. Public health and economic costs of investigating a suspected outbreak of Legionnaires’ disease. Epidemiol. Infect. 136, 1306–1314 (2008).
5. Losick, V. P. & Isberg, R. R. NF-κB translocation prevents host cell death after low-dose challenge by Legionella pneumophila. J. Exp. Med. 203, 2177–2189 (2006).
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