Immunization with a novel Clostridium perfringens epsilon toxin mutant rETXY196E-C confers strong protection in mice
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep24162.pdf
Reference26 articles.
1. Bokori-Brown, M. et al. Clostridium perfringens epsilon toxin mutant Y30A-Y196A as a recombinant vaccine candidate against enterotoxemia. Vaccine 32, 2682–2687, doi: 10.1016/j.vaccine.2014.03.079 (2014).
2. McDonel, J. L. Clostridium perfringens toxins (type A, B, C, D, E). Pharmacology & therapeutics 10, 617–655 (1980).
3. Miyata, S. et al. Cleavage of a C-terminal peptide is essential for heptamerization of Clostridium perfringens epsilon-toxin in the synaptosomal membrane. The Journal of biological chemistry 276, 13778–13783, doi: 10.1074/jbc.M011527200 (2001).
4. Borrmann, E., Gunther, H. & Kohler, H. Effect of Clostridium perfringens epsilon toxin on MDCK cells. FEMS immunology and medical microbiology 31, 85–92 (2001).
5. Nagahama, M., Hara, H., Fernandez-Miyakawa, M., Itohayashi, Y. & Sakurai, J. Oligomerization of Clostridium perfringens epsilon-toxin is dependent upon membrane fluidity in liposomes. Biochemistry (Mosc.) 45, 296–302, doi: 10.1021/bi051805s (2006).
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