Xenotransplantation: current status and a perspective on the future
Author:
Publisher
Springer Science and Business Media LLC
Subject
Energy Engineering and Power Technology,Fuel Technology
Link
http://www.nature.com/articles/nri2099.pdf
Reference139 articles.
1. Cooper, D. K. C., Gollackner, B. & Sachs, D. H. Will the pig solve the transplantation backlog? Annu. Rev. Med. 53, 133–147 (2002).
2. Groth, C. G. et al. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 344, 1402–1404 (1994).
3. Elliott, R. B. et al. Live encapsulated porcine islets from a type 1 diabetic patient 9.5 yr after xenotransplantation. Xenotransplantation 14, 157–161 (2007).
4. Cardona, K. et al. Long-term survival of neonatal porcine islets in nonhuman primates by targeting costimulation pathways. Nature Med. 12, 304–306 (2006).
5. Hering, B. J. et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nature Med. 12, 301–303 (2006). References 4 and 5 show that chronic immunosuppressive protocols based on co-stimulatory blockade allow long-term porcine pancreatic-islet xenograft survival and diabetes reversal in non-human primate recipients. Such immunosuppresive protocols are not yet justified in the clinic because of their complications.
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