iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72

iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72–polymorphic p53

Published:2006-09-10 Issue:10 Volume:38 Page:1133-1141
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Bergamaschi Daniele,Samuels Yardena,Sullivan Alexandra,Zvelebil Marketa,Breyssens Hilde,Bisso Andrea,Del Sal Giannino,Syed Nelofer,Smith Paul,Gasco Milena,Crook Tim,Lu Xin

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng1879.pdf

Reference30 articles.

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2. Samuels-Lev, Y. et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8, 781–794 (2001).

3. Bergamaschi, D. et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat. Genet. 33, 162–167 (2003).

4. Liu, Z.J., Zhang, Y., Zhang, X.B. & Yang, X. Abnormal mRNA expression of ASPP members in leukemia cell lines. Leukemia 18, 880 (2004).

5. Zhang, X., Wang, M., Zhou, C., Chen, S. & Wang, J. The expression of iASPP in acute leukemias. Leuk. Res. 29, 179–183 (2005).

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