Scale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats

Author:

Raigani Mozhgan,Rouini Mohammad-Reza,Golabchifar Ali-Akbar,Mirabzadeh Esmat,Vaziri Behrouz,Barkhordari Farzaneh,Davami Fatemeh,Mahboudi Fereidoun

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference39 articles.

1. Mozaffarian, D. et al. Heart disease and stroke statistics–2015 update: a report from the American Heart Association. Circulation 131, e29–322 (2015).

2. World Health Organization. World Health Statistics 2014. http://apps.who.int/iris/bitstream/10665/112738/1/9789240692671_eng.pdf (Date of access:15/11/2015) (2014).

3. Rouf, S. A., Moo-Young, M. & Chisti, Y. Tissue-type plasminogen activator: characteristics, applications and production technology. Biotechnol Adv 14, 239–266 (1996).

4. Collen, D., Stassen, J. M. & Larsen, G. Pharmacokinetics and thrombolytic properties of deletion mutants of human tissue-type plasminogen activator in rabbits. Blood 71, 216–219 (1988).

5. Kruithof, E. K. O. & Dunoyer-Geindre, S. Human tissue-type plasminogen activator. Thromb Haemost 112, 243–254 (2014).

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