Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/47520.pdf
Reference30 articles.
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2. Barnes,P. J. & Karin,M. Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases. New Engl. J. Med. 336, 1066–1071 (1997).
3. DiDonato,J. A., Hayakawa,M., Rothwarf,D. M., Zandi,E. & Karin,M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388, 548–554 (1997).
4. Zandi,E., Chen,Y. & Karin,M. Direct phosphorylation of IκB by IKKα and IKKβ: discrimination between free and NF-κB-bound substrate. Science 281, 1360–1363 (1998).
5. Herschman,H. R. et al. Function and regulation of prostaglandin synthase-2. Adv. Exp. Med. Biol. 407, 61–66 (1997).
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