The Discovery of Fluoxetine Hydrochloride (Prozac)
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd1821.pdf
Reference89 articles.
1. Wong, D. T., Horng, J. S., Bymaster, F. P., Hauser, K. L. & Molloy, B. B. A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine. Life Sci. 15, 471–479 (1974). This was the first report to describe the discovery, and give a brief characterization, of fluoxetine (LY110140) as a selective inhibitor of 5-HT uptake. The authors considered the possibility that fluoxetine would be an antidepressant drug and a useful research tool.
2. Fuller, R. W., Perry, K. W. & Molloy, B. B. Effect of an uptake inhibitor on serotonin metabolism in rat brain: studies with 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine (Lilly 110140). Life Sci. 15, 1161–1171 (1974). This was the first published study to show the effect of fluoxetine on the metabolism of 5-HT in the rat brain.
3. Fuller, R. W. & Wong, D. T. Inhibition of serotonin uptake. Fed. Proc. Fed. Am. Soc. Exp. Biol. 36, 2154–2158 (1977).
4. Fuller, R. W., Wong, D. T. & Robertson, D. W. Fluoxetine, a selective inhibitor of serotonin uptake. Med. Res. Rev. 11, 17–34 (1991).
5. Wong, D. T., Bymaster, F. P. & Engleman, E. A. Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug (in US): twenty years since its first publication. Life Sci. 57, 411–441 (1995). This review provided the rationale for searching a selective inhibitor of 5-HT uptake and described the comprehensive preclinical pharmacology of fluoxetine.
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