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Scanning the human genome with combinatorial transcription factor libraries

Published:2003-02-18 Issue:3 Volume:21 Page:269-274
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Blancafort Pilar,Magnenat Laurent,Barbas Carlos F.

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt794.pdf

Reference30 articles.

1. Beerli, R.R. & Barbas, C.F. III. Engineering polydactyl zinc-finger transcription factors. Nat. Biotechnol. 12, 632–641 (2002).

2. Brummelkamp, T.R., Benards, R. & Agami, R. A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550–553 (2002).

3. Hiroaki, K., Onuki, R., Suyama, E. & Taira, K. Identification of genes that function in the TNF-α-mediated apoptotic pathway using randomized hybrid ribozyme libraries. Nat. Biotechnol. 20, 376–380 (2002).

4. Walden, R. et al. Activation tagging: a means of isolating genes implicated as playing a role in plant growth and development. Plant Mol. Biol. 26, 1521–1528 (1994).

5. Beerli, R.R., Dreier, B. & Barbas, C.F. III. Positive and negative regulation of endogenous genes by designed transcription factors. Proc. Natl. Acad. USA 97, 1495–1500 (2000).

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