Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics
Link
http://www.nature.com/articles/ng.735.pdf
Reference36 articles.
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2. NICE clinical guideline 87. Type 2 diabetes: the management of type 2 diabetes. (National Institute for Health and Clinical Excellence, London, UK, 2009).
3. Zhou, G. et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167–1174 (2001).
4. Owen, M.R., Doran, E. & Halestrap, A.P. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J. 348, 607–614 (2000).
5. Hawley, S.A. et al. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation. Cell Metab. 11, 554–565 (2010).
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