A non-catalytic role of choline kinase alpha is important in promoting cancer cell survival

Author:

Falcon S C,Hudson C S,Huang Y,Mortimore M,Golec J M,Charlton P A,Weber P,Sundaram H

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Molecular Biology

Reference22 articles.

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2. Cuadrado A, Carnero A, Dolfi F, Kimenez B, Lacal JC . Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Oncogene 1993; 8: 2959–2968.

3. Gibellini F, Smith TK . The Kennedy pathway - De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life 2010; 63: 414–428.

4. Yalcin A, Clem B, Makoni S, Clem A, Nelson K, Thornburg J et al. Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signalling. Oncogene 2009; 29: 139–149.

5. Mori N, Glunde C, Takagi T, Raman V, Bhujwalla Z . Choline kinase down regulation increases the effect of 5-Fluorouracil in breast cancer cell. Cancer Res 2007; 67: 11284–11290.

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