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400 cGy TBI with fludarabine for reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation

  • Published:2008-08-18 Issue:11 Volume:42 Page:715-722
  • ISSN:0268-3369
  • Container-title:Bone Marrow Transplantation
  • language:en
  • Short-container-title:Bone Marrow Transplant

Author:

Sobecks R M,Dean R,Rybicki L A,Chan J,Theil K S,Macklis R,Andresen S,Kalaycio M,Pohlman B,Ferraro C,Cherni K,Sweetenham J,Copelan E,Bolwell B J

Publisher

Springer Science and Business Media LLC

Subject

Transplantation,Hematology

Reference32 articles.

1. Niederwieser D, Maris M, Shizuru J, Petersdorf E, Hegenbart U, Sandmaier B et al. Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with hematological diseases. Blood 2003; 101: 1620–1629.

2. Slavin S, Nagler A, Naparstek E, Kapelushnik Y, Aker M, Cividalli G et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 1998; 91: 756–763.

3. Childs R, Clave E, Contentin N, Jayasekera D, Hensel N, Leitman S et al. Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses. Blood 1999; 94: 3234–3241.

4. Giralt S, Thall PF, Khouri I, Wang X, Braunshweig I, Ippolitti C et al. Melphalan and purine analog-containing preparative regimens: reduced-intensity conditioning for patients with hematologic malignancies undergoing allogeneic progenitor cell transplantation. Blood 2001; 97: 631–637.

5. McSweeney PA, Niederwieser D, Shizuru JA, Sandmaier B, Molina A, Maloney D et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects. Blood 2001; 97: 3390–3400.
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