PD-L1 mRNA expression in plasma-derived exosomes is associated with response to anti-PD-1 antibodies in melanoma and NSCLC

Author:

Del Re Marzia,Marconcini Riccardo,Pasquini Giulia,Rofi Eleonora,Vivaldi Caterina,Bloise Francesco,Restante Giuliana,Arrigoni Elena,Caparello Chiara,Bianco Maria Grazia,Crucitta Stefania,Petrini Iacopo,Vasile Enrico,Falcone Alfredo,Danesi Romano

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference12 articles.

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2. Borghaei H, Paz-Ares L, Horn L, Spigel DR, Steins M, Ready NE, Chow LQ, Vokes EE, Felip E, Holgado E, Barlesi F, Kohlhaufl M, Arrieta O, Burgio MA, Fayette J, Lena H, Poddubskaya E, Gerber DE, Gettinger SN, Rudin CM, Rizvi N, Crino L, Blumenschein GR Jr., Antonia SJ, Dorange C, Harbison CT, Graf Finckenstein F, Brahmer JR (2015) Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N Engl J Med 373: 1627–1639.

3. Cho JH, Sorensen SF, Choi YL, Feng Y, Kim TE, Choi H, Georgsen JB, Dolled-Filhart M, Emancipator K, Meldgaard P, Sun JM, Kim HK, Choi YS, Shim YM, Zhou W, Hager H, Kim J (2017) Programmed death ligand 1 expression in paired non-small cell lung cancer tumor samples. Clin Lung Cancer 18: e473–e479.

4. Del Re M, Biasco E, Crucitta S, Derosa L, Rofi E, Orlandini C, Miccoli M, Galli L, Falcone A, Jenster GW, van Schaik RH, Danesi R (2017) The detection of androgen receptor splice variant 7 in plasma-derived exosomal rna strongly predicts resistance to hormonal therapy in metastatic prostate cancer patients. Eur Urol 71: 680–687.

5. Dudley JC, Lin MT, Le DT, Eshleman JR (2016) Microsatellite instability as a biomarker for PD-1 blockade. Clin Cancer Res 22: 813–820.

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