FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization-Reference-Cited by-同舟云学术

FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization

Published:2015-05-12 Issue:1 Volume:6 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

O-Sullivan InSug,Zhang Wenwei,Wasserman David H.,Liew Chong Wee,Liu Jonathan^ORCID,Paik Jihye,DePinho Ronald A.,Stolz Donna Beer,Kahn C. Ronald,Schwartz Michael W.,Unterman Terry G.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms8079.pdf

Reference32 articles.

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2. Zhang, W. et al. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J. Biol. Chem. 281, 10105–10117 (2006).

3. Zhang, K. et al. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153, 631–646 (2012).

4. Haeusler, R. A., Kaestner, K. H. & Accili, D. FoxOs function synergistically to promote glucose production. J. Biol. Chem. 285, 35245–35248 (2010).

5. Xiong, X., Tao, R., DePinho, R. A. & Dong, X. C. Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. PloS ONE 8, e74340 (2013).

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