JAK–STAT pathway targeting for the treatment of inflammatory bowel disease-Reference-Cited by-同舟云学术

JAK–STAT pathway targeting for the treatment of inflammatory bowel disease

Published:2020-03-19 Issue:6 Volume:17 Page:323-337
ISSN:1759-5045
Container-title:Nature Reviews Gastroenterology & Hepatology
language:en
Short-container-title:Nat Rev Gastroenterol Hepatol

Author:

Salas Azucena^ORCID,Hernandez-Rocha Cristian,Duijvestein Marjolijn^ORCID,Faubion William,McGovern Dermot,Vermeire Severine^ORCID,Vetrano Stefania,Vande Casteele Niels^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Gastroenterology,Hepatology

Link

http://www.nature.com/articles/s41575-020-0273-0.pdf

Reference192 articles.

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2. Yu, H. et al. Market share and costs of biologic therapies for inflammatory bowel disease in the USA. Aliment. Pharmacol. Ther. 47, 364–370 (2018).

3. Lamb, C. A. et al. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut 68 (Suppl. 3), 1–106 (2019).

4. Shuai, K. & Liu, B. Regulation of JAK-STAT signalling in the immune system. Nat. Rev. Immunol. 3, 900–911 (2003).

5. Schwartz, D. M. et al. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat. Rev. Drug Discov. 17, 78 (2017). This review describes the cellular and molecular rationale for JAK inhibition for various chronic inflammatory diseases as well as the efficacy and safety data available from clinical trials, and provides an overview of potential next-generation and future approaches to JAK targeting.

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