Cerebral Blood Flow Studied by Xenon-133 Inhalation Technique in Parkinsonism: Loss of Hyperfrontal Pattern

Abstract

Cerebral blood flow (grey matter flow) in parkinsonism requires further investigation. The noninvasive method of 133Xe inhalation permits study of larger numbers of subjects than previously used invasive techniques such as the intracarotid 133Xe injection method. Measurements were made in this laboratory in 30 subjects having Parkinson's disease. Mean hemispheric blood flow (F1) values were 70.4 ± 9.3 ml/100 g/min, compared to 76.3 for a group of age-matched normal subjects, which is a decrease of −7.8%. The most striking difference was the loss of the “hyperfrontal distribution” in parkinsonism. The prefrontal F1 values were only 1.8% greater than the hemisphere grey matter flow, compared with 8.5% in controls of a similar age group.