Reproducibility of Resting Cerebral Blood Flow Measurements with H215O Positron Emission Tomography in Humans-Reference-Cited by-同舟云学术

Reproducibility of Resting Cerebral Blood Flow Measurements with H215O Positron Emission Tomography in Humans

Published:1993-09 Issue:5 Volume:13 Page:748-754
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Matthew Elizabeth,Andreason Paul¹,Carson Richard E.²,Herscovitch Peter²,Pettigrew Karen³,Cohen Robert¹,King Catherine¹,Johanson Chris-Ellyn⁴,Paul Steven M.

Affiliation:

1. Section on Clinical Brain Imaging, Laboratory of Cerebral Blood Flow and Metabolism

2. Department of Nuclear Medicine, National Institute of Mental Health, National Institutes of Health

3. Division of Epidemiology and Services Research, National Institute of Mental Health, National Institutes of Health

4. Department of Psychiatry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, U.S.A.

Abstract

Two consecutive measurements of resting CBF were carried out in normal volunteers (n = 25) using H215O positron emission tomography. Absolute whole-brain blood flow (WBBF; ml 100 g−1 min−1, mean ± SD) for the first (40.3 ± 6.4) and second (39.3 ± 6.5) measurements was not significantly different (mean % difference 2.3 ± 8.7). Analysis of regions of interest showed no significant differences in absolute regional CBF (rCBF) and normalized (rCBF/WBBF) rCBF. Left-right differences were also not significant. These data demonstrate the reproducibility of resting CBF measurements in normal humans.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1993.95

Reference16 articles.

1. Strategy for the Measurement of Regional Cerebral Blood Flow Using Short-Lived Tracers and Emission Tomography

2. 133Xenon inhalation method. Analysis of reproducibility: some of its physiological implications.

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