Hyperthermia-Induced Neuronal Protection against Ischemic Injury in Gerbils-Reference-Cited by-同舟云学术

Hyperthermia-Induced Neuronal Protection against Ischemic Injury in Gerbils

Published:1991-05 Issue:3 Volume:11 Page:449-452
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Kitagawa Kazuo,Matsumoto Masayasu,Tagaya Masafumi,Kuwabara Keisuke,Hata Ryuji,Handa Nobuo,Fukunaga Ryuzo,Kimura Kazufumi¹,Kamada Takenobu

Affiliation:

1. Biomedical Research Center, Osaka University Medical School, Osaka, Japan

Abstract

We investigated the effect of hyperthermic pretreatment before induction of ischemia using a gerbil model of 5-min forebrain ischemia. A single hyperthermic treatment 18 h before ischemia exhibited a partial protective effect, and repetitive hyperthermic pretreatments at 18-h intervals before ischemia showed clear protection against neuronal death in the CA1 area of the hippocampus, whereas single hyperthermic treatment 3, 6, 24, or 50 h before ischemia exhibited little protective effect. This transient and cumulative neuroprotective effect of hyperthermic pretreatment strongly suggested the involvement of stress reactions after hyperthermia in the protective mechanism against ischemic neuronal death.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1991.86

Reference14 articles.

1. Hyperthermia Protects Against Light Damage in the Rat Retina

2. Small Differences in Intraischemic Brain Temperature Critically Determine the Extent of Ischemic Neuronal Injury

3. Transient hyperthermia protects against subsequent forebrain ischemic cell damage in the rat

4. Induced thermal resistance in HeLa cells

5. Delayed neuronal death in the gerbil hippocampus following ischemia

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