Affiliation:
1. Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, U.S.A.
Abstract
This article describes a simplified method for the determination of the l-[18F]6-fluorodopa (FDOPA) fraction time course that takes advantage of the strong correlation between the radioactivity ratio (metabolites/FDOPA) and time. Serial arterial blood samples are collected for assay of plasma total radioactivities following an intravenous injection of FDOPA into carbidopa-pretreated subjects. In addition, a single plasma sample, collected late in the study and analyzed for FDOPA fraction, is sufficient to determine accurately the time course of the FDOPA concentration in plasma. The validated straight-line method greatly simplifies blood analysis for routine positron emission tomography FDOPA studies.
Subject
Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology
Cited by
10 articles.
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