Affiliation:
1. Medizinisches Zentrum für Pathologie, Abteilung Neuropathologie, Marburg, F.R.G.
Abstract
We investigated the effect of the known antagonist of platelet-activating factor (PAF), ginkgolide B, on postischemic neuronal damage in the rat. Neuronal necroses were evaluated in the hippocampus 7 days after a 10-min forebrain ischemia. Preischemic application of ginkgolide B (50 mg/kg p.o.) significantly reduced neuronal damage. It is suggested that the antagonism of PAF is responsible for this beneficial effect of ginkgolide B.
Subject
Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology
Cited by
116 articles.
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