Relations between Neuropsychological and Cerebral Metabolic Asymmetries in Early Alzheimer's Disease

Author:

Haxby James V.1,Duara Ranjan1,Grady Cheryl L.1,Cutler Neal R.1,Rapoport Stanley I.1

Affiliation:

1. Section on Brain Aging and Dementia, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, U.S.A.

Abstract

Regional CMRglc (rCMRglc) values were determined with positron emission tomography (PET) in 10 patients with mild to moderate clinically diagnosed Alzheimer's disease (AD) and in 26 healthy controls. rCMRglc in frontal, parietal, and temporal association cortices were significantly more laterally asymmetrical in AD patients than in controls (p < 0.05). Furthermore, lateral asymmetry of rCMRglc in AD patients but not in the control subjects correlated significantly with asymmetry of language and visuospatial functions such that lower left than right rCMRglc was associated with relatively greater impairment of language and vice versa. The results demonstrate that discrepancies between language and visuospatial deficits in patients with early AD are related to asymmetrical reductions in cerebral cortical glucose metabolism.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

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