Two-Day Starvation Does Not Alter the Kinetics of Blood-Brain Barrier Transport and Phosphorylation of Glucose in Rat Brain-Reference-Cited by-同舟云学术

Two-Day Starvation Does Not Alter the Kinetics of Blood-Brain Barrier Transport and Phosphorylation of Glucose in Rat Brain

Published:1985-03 Issue:1 Volume:5 Page:40-46
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Crane Paul D.,Pardridge William M.¹,Braun Leon D.²³,Oldendorf William H.²³

Affiliation:

1. Departments of Medicine, School of Medicine, University of California-Los Angeles, California, U.S.A.

2. Departments of Neurology and Psychiatry, School of Medicine, University of California-Los Angeles, California, U.S.A.

3. Departments of Research Service, Veterans Administration Medical Center, Brentwood Division, Los Angeles, California, U.S.A.

Abstract

The blood-brain barrier (BBB) transport and brain phosphorylation of glucose were assessed in conscious rats subjected to 2 days of starvation. Although plasma glucose decreased, no significant changes in brain blood flow, BBB glucose transport, or 2-deoxy-d-glucose phosphorylation were observed. The data suggest that adaptive changes of brain glucose metabolism previously observed in starvation are located beyond the initial steps of brain entry and phosphorylation.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Neurology (clinical),Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1985.6

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