Effects of Xenon and Krypton on Regional Cerebral Blood Flow in the Rat-Reference-Cited by-同舟云学术

Effects of Xenon and Krypton on Regional Cerebral Blood Flow in the Rat

Published:1985-03 Issue:1 Volume:5 Page:126-132
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Junck L.¹,Dhawan V.¹,Thaler H. T.¹,Rottenberg D. A.¹

Affiliation:

1. Department of Neurology and Biostatistics Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, U.S.A.

Abstract

The effects of high inspired concentrations of xenon and krypton on regional CBF (rCBF) were assessed in the rat using [14C]iodoantipyrine and quantitative autoradiography. Inhalation of 80% xenon for 1 or 2 min and inhalation of 40% xenon for 2 min were found to have significant effects on rCBF, including average increases of 75–96% in cerebral neocortical regions. Inhalation of 40% xenon for 1 min and of 80% krypton for 2 min had no significant effect on rCBF in most brain regions studied. If xenon inhalation produces effects on rCBF in humans similar to those observed in the rat, such effects could be an important source of error in xenon computed tomography rCBF studies.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1985.16

Reference37 articles.

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