In vivo Measurement of Regional Cerebral Haematocrit Using Positron Emission Tomography-Reference-Cited by-同舟云学术

In vivo Measurement of Regional Cerebral Haematocrit Using Positron Emission Tomography

Published:1984-09 Issue:3 Volume:4 Page:317-322
ISSN:0271-678X
Container-title:Journal of Cerebral Blood Flow & Metabolism
language:en
Short-container-title:J Cereb Blood Flow Metab

Author:

Lammertsma Adriaan A.¹,Brooks David J.¹,Beaney Ronald P.¹,Turton David R.¹,Kensett Malcolm J.¹,Heather Jon D.¹,Marshall John¹,Jones Terry¹

Affiliation:

1. MRC Cyclotron Unit, Hammersmith Hospital, London, England

Abstract

A method is described for measuring the regional cerebral-to-large vessel haematocrit ratio using inhalation of carbon-11-labelled carbon monoxide and the intravenous injection of carbon-11-labelled methyl-albumin in combination with positron emission tomography. The mean value in a series of nine subjects was 0.69. This is ∼20% lower than the value of 0.85 previously reported. It is concluded that previous measurements of regional cerebral blood volume using a haematocrit ratio of 0.85 will have underestimated the value of regional cerebral blood volume by 20%.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine,Clinical Neurology,Neurology

Link

http://journals.sagepub.com/doi/pdf/10.1038/jcbfm.1984.47

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