Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors-Reference-Cited by-同舟云学术

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Small molecule RITA binds to p53, blocks p53–HDM-2 interaction and activates p53 function in tumors

Published:2004-11-21 Issue:12 Volume:10 Page:1321-1328
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Issaeva Natalia,Bozko Przemyslaw,Enge Martin,Protopopova Marina,Verhoef Lisette G G C,Masucci Maria,Pramanik Aladdin,Selivanova Galina

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm1146.pdf

Reference46 articles.

1. Vogelstein, B., Lane, D. & Levine, A.J. Surfing the p53 network. Nature 408, 307–310 (2000).

2. Olivier, M. et al. The IARC TP53 database: new online mutation analysis and recommendations to users. Hum. Mutat. 19, 607–614 (2002).

3. Chene, P. Inhibiting the p53–MDM2 interaction: an important target for cancer therapy. Nat. Rev. Cancer 3, 102–109 (2003).

4. Prives, C. Signaling to p53: breaking the MDM2-p53 circuit. Cell 95, 5–8 (1998).

5. Montes de Oca Luna, R., Wagner, D.S. & Lozano, G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378, 203–206 (1995).

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