Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells-Reference-Cited by-同舟云学术

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

Published:2017-10-30 Issue:12 Volume:49 Page:1779-1784
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Meyers Robin M^ORCID,Bryan Jordan G,McFarland James M,Weir Barbara A,Sizemore Ann E,Xu Han,Dharia Neekesh V^ORCID,Montgomery Phillip G^ORCID,Cowley Glenn S,Pantel Sasha,Goodale Amy,Lee Yenarae,Ali Levi D,Jiang Guozhi,Lubonja Rakela,Harrington William F,Strickland Matthew,Wu Ting,Hawes Derek C,Zhivich Victor A,Wyatt Meghan R,Kalani Zohra,Chang Jaime J,Okamoto Michael,Stegmaier Kimberly,Golub Todd R^ORCID,Boehm Jesse S^ORCID,Vazquez Francisca,Root David E,Hahn William C^ORCID,Tsherniak Aviad^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng.3984.pdf

Reference27 articles.

1. Wang, T. et al. Identification and characterization of essential genes in the human genome. Science 350, 1096–1101 (2015).

2. Hart, T. et al. High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities. Cell 163, 1515–1526 (2015).

3. Aguirre, A.J. et al. Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting. Cancer Discov. 6, 914–929 (2016).

4. Munoz, D.M. et al. CRISPR screens provide a comprehensive assessment of cancer vulnerabilities but generate false-positive hits for highly amplified genomic regions. Cancer Discov. 6, 900–913 (2016).

5. Cheung, H.W. et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc. Natl. Acad. Sci. USA 108, 12372–12377 (2011).

Cited by 1522 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The immunological landscape and silico analysis of key paraptosis regulator LPAR1 in gastric cancer patients;Translational Oncology;2024-11

2. Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage;Nature Communications;2024-09-09

3. A protein expression atlas on tissue samples and cell lines from cancer patients provides insights into tumor heterogeneity and dependencies;Nature Cancer;2024-09-03

4. METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma;Journal of Hematology & Oncology;2024-09-02

5. How does CHD4 slide nucleosomes?;Biochemical Society Transactions;2024-09-02