An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep18397.pdf
Reference43 articles.
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3. Tytgat, J. et al. A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. Trends.Pharmacol Sci 20, 444–447 (1999).
4. Wulff, H. et al. The voltage-gated Kv1.3 K + channel in effector memory T cells as new target for MS. J.Clin.Invest 111, 1703–1713 (2003).
5. Beeton, C. et al. Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc.Natl.Acad.Sci.USA 103, 17414–17419 (2006).
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