When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40-Reference-Cited by-同舟云学术

When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40

Published:2007-02 Issue:2 Volume:8 Page:136-140
ISSN:1469-221X
Container-title:EMBO reports
language:en
Short-container-title:EMBO Rep

Author:

Wolfe Michael S¹

Affiliation:

1. Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Harvard Institute of Medicine 754 Boston Massachusetts 02115 USA

Publisher

EMBO

Subject

Genetics,Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1038/sj.embor.7400896

Reference54 articles.

1. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

2. Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease

3. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

4. Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

5. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

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