RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis-Reference-Cited by-同舟云学术

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RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

Published:2015-09-09 Issue:2 Volume:69 Page:121-123
ISSN:0021-8820
Container-title:The Journal of Antibiotics
language:en
Short-container-title:J Antibiot

Author:

Kakeya Hideaki,Kaida Daisuke,Sekiya Hiromi,Nagai Koji,Yoshida Minoru,Osada Hiroyuki

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Link

http://www.nature.com/articles/ja201594.pdf

Reference25 articles.

1. Kerbel, R. & Folkman, J. Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727–739 (2002).

2. Jubb, A. M., Oates, A. J., Holden, S. & Koeppen, H. Predicting benefit from anti-angiogenic agents in malignancy. Nat. Rev. Cancer 6, 626–635 (2006).

3. Weis, S. M. & Cheresh, D. A. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat. Med. 17, 1359–1370 (2011).

4. Kakeya, H. et al. Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites. J. Am. Chem. Soc. 124, 3496–3497 (2002).

5. Kakeya, H., Onose, R., Yoshida, A., Koshino, H. & Osada, H. Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity. J. Antibiot. (Tokyo) 55, 829–831 (2002).

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