Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function-Reference-Cited by-同舟云学术

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Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

Published:2012-11-25 Issue:1 Volume:20 Page:46-52
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Baker Rachael,Lewis Steven M,Sasaki Atsuo T,Wilkerson Emily M,Locasale Jason W,Cantley Lewis C,Kuhlman Brian,Dohlman Henrik G,Campbell Sharon L

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.2430.pdf

Reference46 articles.

1. Cox, A.D. & Der, C.J. The dark side of Ras: regulation of apoptosis. Oncogene 22, 8999–9006 (2003).

2. Kjeldgaard, M., Nyborg, J. & Clark, B.F. The GTP binding motif: variations on a theme. FASEB J. 10, 1347–1368 (1996).

3. Herrmann, C. Ras-effector interactions: after one decade. Curr. Opin. Struct. Biol. 13, 122–129 (2003).

4. Scheffzek, K. et al. The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277, 333–339 (1997).

5. Sprang, S. GEFs: master regulators of G-protein activation. Trends Biochem. Sci. 26, 266–267 (2001).

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