Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy-Reference-Cited by-同舟云学术

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Structure-based design of a hyperthermostable AgUricase for hyperuricemia and gout therapy

Published:2019-06-28 Issue:10 Volume:40 Page:1364-1372
ISSN:1671-4083
Container-title:Acta Pharmacologica Sinica
language:en
Short-container-title:Acta Pharmacol Sin

Author:

Shi Yi,Wang Ting,Zhou X. Edward,Liu Qiu-feng,Jiang Yi,Xu H. Eric

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Link

http://www.nature.com/articles/s41401-019-0269-x.pdf

Reference43 articles.

1. Nuki G. Uricase therapy of gout. In Gout and Other Crystal Arthropathies. Elsevier Inc.; 2012. 174–86.

2. Kratzer JT, Lanaspa MA, Murphy MN, Cicerchi C, Graves CL, Tipton PA, et al. Evolutionary history and metabolic insights of ancient mammalian uricases. Proc Natl Acad Sci U S A. 2014;111:3763–8.

3. Abeles AM. Hyperuricemia, gout, and cardiovascular disease: an update. Curr Rheumatol Rep. 2015;17:13.

4. Nyborg AC, Ward C, Zacco A, Chacko B, Grinberg L, Geoghegan JC, et al. A therapeutic uricase with reduced immunogenicity risk and improved development properties. PLoS One. 2016;11:e0167935.

5. Jiskoot W, Randolph TW, Volkin DB, Middaugh CR, Schoneich C, Winter G, et al. Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release. J Pharm Sci. 2012;101:946–54.

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