Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract

Author:

Cheng Wenjun,Liu Jinsong,Yoshida Hiroyuki,Rosen Daniel,Naora Honami

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference40 articles.

1. Feeley, K.M. & Wells, M. Precursor lesions of ovarian epithelial malignancy. Histopathology 38, 87–95 (2001).

2. Auersperg, N., Wong, A.S., Choi, K.C., Kang, S.K. & Leung, P.C. Ovarian surface epithelium: Biology, endocrinology, and pathology. Endocr. Rev. 22, 255–288 (2001).

3. Shih, I. & Kurman, R.J. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am. J. Pathol. 164, 1511–1518 (2004).

4. Mills, G.B. et al. The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy. Semin. Oncol. 28, 125–141 (2001).

5. Enomoto, T., Weghorst, C.M., Inoue, M., Tanizawa, O. & Rice, J.M. K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary. Am J Pathol. 139, 777–785 (1991).

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