Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer

Author:

Codony-Servat Jordi,Cuatrecasas Miriam,Asensio Elena,Montironi Carla,Martínez-Cardús Anna,Marín-Aguilera Mercedes,Horndler Carlos,Martínez-Balibrea Eva,Rubini Michele,Jares Pedro,Reig Oscar,Victoria Iván,Gaba Lydia,Martín-Richard Marta,Alonso Vicente,Escudero Pilar,Fernández-Martos Carlos,Feliu Jaime,Méndez Jose Carlos,Méndez Miguel,Gallego Javier,Salud Antonieta,Rojo Federico,Castells Antoni,Prat Aleix,Rosell Rafael,García-Albéniz Xabier,Camps Jordi,Maurel Joan

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Reference36 articles.

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2. Alonso-Espinaco V, Cuatrecasas M, Alonso V, Escudero P, Marmol M, Horndler C, Ortego J, Gallego R, Codony-Servat J, García-Albéniz X, Jares P, Castells A, Lozano JJ, Rosell R, Maurel J (2014) RAC1b overexpression correlates with poor prognosis in KRAS/BRAF WT metastatic colorectal cancer patients treated with first-line FOLFOX/XELOX chemotherapy. Eur J Cancer 50: 1973–1981.

3. Alonso-Orduna V, Marmol M, Escudero P, Salud A, Safont MJ, Méndez JC, García-Girón C, Martín M, Fernandez-Martos C, García-Albéniz X, Feliu J, Maurel J (2014) 599PA validation of current prognostic scores in metastatic colorectal cancer (mCRC) and a new prognostic score (a GEMCAD Study). Ann Oncol 25: iv204–iv204.

4. Alonso V, Emperador PE, Urena MM, Gallego J, Rodriguez JR, Fernández J, Salud A, Falcó E, Manzano H, Zanui M, Gil M, Sarmiento UB, Martos CF, Calderero V, Ferrer AI, Cuatrecasas M, Rojo F, Feliu J, Maurel J, García-Albéniz X (2016) Prospective evaluation of BRAF, PI3K and PTEN as predictive and prognostic biomarkers in first-line advanced KRAS wild-type colorectal cancer treated with FOLFOX or FOLFIRI plus bi-weekly cetuximab. GEMCAD 10-02. Ann Oncol 27 (Suppl 6): vi149–vi206.

5. Barras D, Missiaglia E, Wirapati P, Sieber OM, Jorissen RN, Love C, Molloy PL, Jones IT, McLaughlin S, Gibbs P, Guinney J, Simon IM, Roth AD, Bosman FT, Tejpar S, Delorenzi M (2017) BRAF V600E mutant colorectal cancer subtypes based on gene expression. Clin Cancer Res 23: 104–115.

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