Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells-Reference-Cited by-同舟云学术

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

Published:2010-01-31 Issue:3 Volume:11 Page:257-264
ISSN:1529-2908
Container-title:Nature Immunology
language:en
Short-container-title:Nat Immunol

Author:

Park Jung-Hyun,Adoro Stanley,Guinter Terry,Erman Batu,Alag Amala S,Catalfamo Marta,Kimura Motoko Y,Cui Yongzhi,Lucas Philip J,Gress Ronald E,Kubo Masato,Hennighausen Lothar,Feigenbaum Lionel,Singer Alfred

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Link

http://www.nature.com/articles/ni.1840.pdf

Reference50 articles.

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2. Singer, A. New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision. Curr. Opin. Immunol. 14, 207–215 (2002).

3. Surh, C.D. & Sprent, J. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372, 100–103 (1994).

4. Van De Wiele, C.J. et al. Thymocytes between the β-selection and positive selection checkpoints are nonresponsive to IL-7 as assessed by STAT-5 phosphorylation. J. Immunol. 172, 4235–4244 (2004).

5. Yu, Q. et al. Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. J. Exp. Med. 203, 165–175 (2006).

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