The Inflammatory Bowel Disease Transcriptome and Metatranscriptome Meta-Analysis (IBD TaMMA) framework

Author:

Massimino LucaORCID,Lamparelli Luigi AntonioORCID,Houshyar Yashar,D’Alessio Silvia,Peyrin-Biroulet Laurent,Vetrano Stefania,Danese Silvio,Ungaro FedericaORCID

Abstract

AbstractInflammatory bowel disease (IBD) is a class of chronic disorders whose etiogenesis is still unknown. Despite the high number of IBD-related omics studies, the RNA-sequencing data produced results that are hard to compare because of the experimental variability and different data analysis approaches. We here introduce the IBD Transcriptome and Metatranscriptome Meta-Analysis (TaMMA) framework, a comprehensive survey of publicly available IBD RNA-sequencing datasets. IBD TaMMA is an open-source platform where scientists can explore simultaneously the freely available IBD-associated transcriptomics and microbial profiles thanks to its interactive interface, resulting in a useful tool to the IBD community.

Funder

Innovative Medicines Initiative

Fondazione Cariplo

Fondazione Amici ONLUS ITALIA, research prize to FU

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

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