Killing the messenger: short RNAs that silence gene expression
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm1129.pdf
Reference114 articles.
1. Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806–811 (1998). The first evidence that dsRNA could mediate sequence-specific gene silencing. Silencing was shown to be heritable from parental C. elegans to their progeny.
2. Jorgensen, R. Altered gene expression in plants due to trans interactions between homologous genes. Trends Biotechnol. 8, 340–344 (1990).
3. Romano, N. & Macino, G. Quelling: transient inactivation of gene expression in Neurospora crassa by transformation with homologous sequences. Mol. Microbiol. 6, 3343–3353 (1992). Evidence that the ectopic expression of segments of transgenes leads to silencing of the endogenous homologues. This process is known as 'quelling' in Neurospora and is related to PTGS in plants and RNAi in animals.
4. Bernstein, E., Denli, A. M. & Hannon, G. J. The rest is silence. RNA 7, 1509–1521 (2001).
5. Grishok, A., Tabara, H. & Mello, C. C. Genetic requirements for inheritance of RNAi in C. elegans. Science 287, 2494–2497 (2000). This study begins to assemble the genes that are involved in RNAi into a pathway and explain the genetic requirements of inheritance of RNAi phenotypes from parents to offspring.
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