Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis-Reference-Cited by-同舟云学术

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

Published:2010-02-07 Issue:3 Volume:16 Page:308-312
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Yadav Vijay K,Balaji Santhanam,Suresh Padmanaban S,Liu X Sherry,Lu Xin,Li Zhishan,Guo X Edward,Mann J John,Balapure Anil K,Gershon Michael D,Medhamurthy Rudraiah,Vidal Marc,Karsenty Gerard,Ducy Patricia

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.2098.pdf

Reference25 articles.

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2. Yadav, V.K. et al. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135, 825–837 (2008).

3. Liu, Q. et al. Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J. Pharmacol. Exp. Ther. 325, 47–55 (2008).

4. Shi, Z.C. et al. Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J. Med. Chem. 51, 3684–3687 (2008).

5. Yadav, V.K. et al. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite and energy expenditure. Cell 138, 976–989 (2009).

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