Letter to the editor regarding recent publication titled “Developing an internal threshold of toxicological concern (iTTC)” by Arnot et al. (2022)
Author:
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health,Pollution,Toxicology,Epidemiology
Link
https://www.nature.com/articles/s41370-023-00571-9.pdf
Reference11 articles.
1. Munro IC, Ford RA, Kennepohl E, Sprenger JG. Correlation of structural class with no-observed-effect levels: a proposal for establishing a threshold of concern. Food Chem Toxicol. 1996;34:829–67. https://doi.org/10.1016/S0278-6915(96)00049-X.
2. Rogiers V, Benfenati E, Bernauer U, Bodin L, Carmichael P, Chaudhry Q, et al. The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings. Toxicology. 2020;436:152421. https://doi.org/10.1016/j.tox.2020.152421.
3. Bessems JGM, Paini A, Gajewska M, Worth A. The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data – a case study with caffeine. Toxicology. 2017;392:119–29. https://doi.org/10.1016/j.tox.2017.03.012.
4. Ellison CA, Blackburn KL, Carmichael PL, Clewell HJ 3rd, Cronin MTD, Desprez B, et al. Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop. Regul Toxicol Pharmacol. 2019;103:63–72. https://doi.org/10.1016/j.yrtph.2019.01.016.
5. Ellison CA, Api AM, Becker RA, Efremenko AY, Gadhia S, Hack CE, et al. Internal Threshold of Toxicological Concern (iTTC): where we are today and what is possible in the near future. Front Toxicol. 2021;2:621541. https://doi.org/10.3389/ftox.2020.621541.
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