Abstract
Abstract
Background
Food and Drug Administration (FDA) Food Drug and Cosmetic (FD&C) synthetic color additives (SCAs) have been associated with attentional and behavioral problems in children. Efforts to quantify exposure have focused on foods, while the contribution of medications and supplements remains unknown.
Objective
To estimate exposures to SCAs in children (2–16 years) and pregnant women from intake of common over-the-counter (OTC) medications and vitamins.
Methods
We estimated single-day exposure (mg/kg/day) to FD&C SCAs based on measurements of 25 different products and recommended dosages on product labels. Exposures were compared to SCA exposure estimates from food we previously developed and acceptable daily intakes (ADIs) established by FDA and the World Health Organization.
Results
The highest exposure was found for FD&C Red No. 40 in a children’s cold/cough/allergy syrup. A child aged 12–16 years consuming the maximum daily dosage would have an exposure of 0.221 mg/kg/day, which is twice this age group’s typical exposure to this additive from food. No estimated exposures exceeded the ADIs.
Significance
Some children’s OTC medications and vitamins may cause daily SCA exposures comparable to those from foods. OTC medications and vitamins should be considered in efforts to quantify population exposure to FD&C SCAs.
Impact
Exposure to synthetic color additives (SCAs) from foods has been associated with behavioral problems in children. Exposures from over-the-counter (OTC) medications and vitamins remain unquantified despite widespread use. We estimated exposures in children and pregnant women for 25 different OTC medication and vitamin products sold in the United States. While exposures were below acceptable daily intakes (ADIs) established by the US Food and Drug Administration and the World Health Organization, some were comparable to typical daily exposures from foods. This work critically informs future SCA exposure assessments and provides valuable information for parents concerned about the health effects of SCAs.
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health,Pollution,Toxicology,Epidemiology
Reference23 articles.
1. OEHHA (Office on Environmental Health Hazard Assessment). Final Report. Environmental health risk assessment of artificial food colors for women of childbearing age, pregnant women and children [Internet]. 2020. https://oehha.ca.gov/risk-assessment/public-comment-period-general-info/announcement-release-public-review-draft-health.
2. Nigg JT, Lewis K, Edinger T, Falk M. Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry. 2012;51:86–97.e8.
3. Noorafshan A, Hashemi M, Karbalay-Doust S, Karimi F. High dose Allura Red, rather than the ADI dose, induces structural and behavioral changes in the medial prefrontal cortex of rats and taurine can protect it. Acta Histochem. 2018;120:586–94.
4. Tanaka T, Takahashi O, Inomata A, Ogata A, Nakae D. Reproductive and neurobehavioral effects of brilliant blue fcf in mice. Birth Defects Res B Dev Reprod Toxicol. 2012;95:395–409.
5. FDA. Background Document for the Food Advisory Committee: Certified Color Additives in Food and Possible Association with Attention Deficit Hyperactivity Disorder in Children March 30–31, 2011. FDA; 2011.
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