Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase-Reference-Cited by-同舟云学术

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

Published:2010-06-27 Issue:7 Volume:28 Page:738-742
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Aghajan Mariam,Jonai Nao,Flick Karin,Fu Fei,Luo Manlin,Cai Xiaolu,Ouni Ikram,Pierce Nathan,Tang Xiaobo,Lomenick Brett,Damoiseaux Robert,Hao Rui,del Moral Pierre M,Verma Rati,Li Ying,Li Cheng,Houk Kendall N,Jung Michael E,Zheng Ning,Huang Lan,Deshaies Raymond J,Kaiser Peter,Huang Jing

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.1645.pdf

Reference40 articles.

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3. Petroski, M.D. & Deshaies, R.J. Function and regulation of cullin-RING ubiquitin ligases. Natl. Rev. 6, 9–20 (2005).

4. Easton, J.B. & Houghton, P.J. mTOR and cancer therapy. Oncogene 25, 6436–6446 (2006).

5. Cloughesy, T.F. et al. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 5, e8 (2008).

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