The complex structure and dynamic evolution of human subtelomeres
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg727.pdf
Reference130 articles.
1. Trask, B. J. et al. Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. Hum. Mol. Genet. 7, 13–26 (1998).A demonstration of the striking human variation in number and chromosomal location of olfactory receptor genes that are contained in a subtelomeric block.
2. Freitas-Junior, L. H. et al. Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum. Nature 407, 1018–1022 (2000).This paper shows that the subtelomerically located var genes in P. falciparum undergo elevated levels of ectopic recombination, which promotes the diversity of antigenic and adhesive phenotypes.
3. Taylor, H. M., Kyes, S. A. & Newbold, C. I. Var gene diversity in Plasmodium falciparum is generated by frequent recombination events. Mol. Biochem. Parasitol. 110, 391–397 (2000).
4. Van Overveld, P. G. et al. Interchromosomal repeat array interactions between chromosomes 4 and 10: a model for subtelomeric plasticity. Hum. Mol. Genet. 9, 2879–2884 (2000).
5. Mefford, H. C., Linardopoulou, E., Coil, D., van den Engh, G. & Trask, B. J. Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes. Hum. Mol. Genet. 10, 2363–2372 (2001).This study compared sequences of a subtelomeric block on different chromosomes from different individuals to infer that ectopic exchanges regularly occur among human subtelomeres.
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