Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1-Reference-Cited by-同舟云学术

Loss of TRP53 reduces but does not overcome dependency of lymphoma cells on MCL-1

Published:2022-01-28 Issue:5 Volume:29 Page:1074-1076
ISSN:1350-9047
Container-title:Cell Death & Differentiation
language:en
Short-container-title:Cell Death Differ

Author:

Aubrey Brandon J.^ORCID,Brennan Margs S.,Diepstraten Sarah T.^ORCID,Wang Zilu,Chang Catherine,Herold Marco J.^ORCID,Strasser Andreas^ORCID,Kelly Gemma L.^ORCID

Funder

Leukaemia Foundation National Research Program Clinical PhD Scholarship

Cancer Council Victoria

Leukaemia Foundation PhD Scholarship

Department of Health | National Health and Medical Research Council

Leukemia and Lymphoma Society

Anthony Redstone Estate

Victorian Cancer Agency

Leukemia Foundation Australia, Dyson Bequest, Craig Perkins Cancer Fund

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

https://www.nature.com/articles/s41418-022-00946-9.pdf

Reference7 articles.

1. Beroukhim R, Mermel C, Porter D, Wei G, Raychaudhuri S, Donovan J, et al. The landscape of somatic copy-number alteration across human cancers. Nature. 2010;463:899–905.

2. Kelly GL, Grabow S, Glaser SP, Fitzsimmons L, Aubrey BJ, Okamoto T, et al. Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53. Genes Dev. 2014;28:58–70.

3. Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, et al. The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature. 2016;538:477–82.

4. Grabow S, Delbridge AR, Aubrey BJ, Vandenberg CJ, Strasser A. Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis. Cell Rep. 2016;14:2337–47.

5. Brinkmann K, Grabow S, Hyland CD, Teh CE, Alexander WS, Herold MJ, et al. The combination of reduced MCL-1 and standard chemotherapeutics is tolerable in mice. Cell Death Differ. 2017;24:2032–43.

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