Mechanisms of quality control differ in male and female germ cells
Author:
Funder
AIRC grant (IG-22206) Ministry of Health
Deutsche Forschungsgemeinschaft
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/s41418-021-00818-8.pdf
Reference16 articles.
1. Suh EK, Yang A, Kettenbach A, Bamberger C, Michaelis AH, Zhu Z, et al. p63 protects the female germ line during meiotic arrest. Nature. 2006;444:624–8.
2. Deutsch GB, Zielonka EM, Coutandin D, Weber TA, Schafer B, Hannewald J, et al. DNA damage in oocytes induces a switch of the quality control factor TAp63alpha from dimer to tetramer. Cell. 2011;144:566–76.
3. Bolcun-Filas E, Rinaldi VD, White ME, Schimenti JC. Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway. Science. 2014;343:533–6.
4. Tuppi M, Kehrloesser S, Coutandin DW, Rossi V, Luh LM, Strubel A, et al. Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63. Nat Struct Mol Biol. 2018;25:261–9.
5. Gebel J, Tuppi M, Chaikuad A, Hotte K, Schroder M, Schulz L, et al. p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Nat Chem Biol. 2020;16:1078–86.
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