Extreme conservation of the poly-glutamine tract in huntingtin is related to neurodevelopmental functions: the “better” may become the “enemy of the good” in the course of evolution
Author:
Funder
Agence Nationale de la Recherche
H2020 partnership ERA NET eRARE 'treatpolyQ'
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
https://www.nature.com/articles/s41418-021-00927-4.pdf
Reference15 articles.
1. The Huntington’s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell. 1993;72:971–83. https://doi.org/10.1016/0092-8674(93)90585-e
2. Walker FO. Huntington’s disease. Lancet Lond Engl. 2007;369:218–28.
3. Bates GP, Dorsey R, Gusella JF, Hayden MR, Kay C, Leavitt BR, et al. Huntington disease. Nat Rev Dis Prim. 2015;1:15005. https://doi.org/10.1038/nrdp.2015.5.
4. Barnat M, Capizzi M, Aparicio E, Boluda S, Wennagel D, Kacher R, et al. Huntington’s disease alters human neurodevelopment. Science. 2020;369:787–93. https://doi.org/10.1126/science.aax3338
5. Saudou F, Humbert S. The biology of huntingtin. Neuron. 2016;89:910–26. https://doi.org/10.1016/j.neuron.2016.02.003
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